Week 1 College Football Predictions: Notre Dame-Wisconsin, Louisville-Ole Miss Picks on Kalshi and Polymarket
Louisville – Ole Miss (Nissan Stadium, Nashville)
The matchup between Louisville and Ole Miss is priced on the Kalshi market at $0.29 for a Louisville win and $0.71 for an Ole Miss victory. According to SportsLine's projection model, which runs 10,000 simulations for each FBS game, the Rebels are projected to win 33-22.
Louisville finished the 2025 season with a 9-4 record (4-4 in ACC) under head coach Jeff Brohm. In the final week of the season, they defeated Kentucky and won the Boca Raton Bowl against Toledo. For the season opener, coach Brohm has selected Lincoln Kienholz as the starting quarterback — the fourth transfer to start the season in this role over four years. Kienholz spent three years at Ohio State, where he recorded 139 passing yards and one touchdown in seven appearances, completing 11 of 14 passes.
Wisconsin – Notre Dame (Lambeau Field, Green Bay)
Ole Miss returns with its best performance in recent years, finishing with a 13-2 record (7-1 in SEC) and earning its first College Football Playoff appearance. Pete Golding, named official head coach after replacing Lane Kiffin in the playoff, led the team to a Fiesta Bowl semifinal loss to Miami. Quarterback Trinidad Chambliss accumulated 3,937 passing yards — the highest total in the SEC — with 22 touchdowns and just three interceptions, adding 527 rushing yards and eight touchdowns.
Alongside the Tennessee game, Sunday will also feature the duel between Wisconsin and Notre Dame, with odds of $0.09 for a Badgers win and $0.92 for a Fighting Irish victory. The Badgers finished the 2025 season with a 4-8 record (2-7 in Big Ten) under head coach Luke Fickell. For the season opener, coach Fickell has selected Colton Joseph, former Old Dominion quarterback, as the starter. In his first two college seasons, Joseph threw for 4,251 yards, recorded 32 touchdowns and 15 interceptions, completing 306 of 512 passes.
In the Big Ten standings, Wisconsin finished last, while Notre Dame enters the competition with a $0.92 odds for victory, indicating high expectations from supporters.
How to Take Advantage of Available Promotions
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These details include all essential figures and facts needed to make informed decisions in the first week of college football, and SportsLine's advanced simulation model provides a solid foundation for any wager. Enjoy trading and supporting your favorite teams!